Recombinant protein which are used in medical practice

For treating hepatitis C 4. For treating haemophilia 5. For prevention of blood clots 6. For treatment of Anaemia 7. For treating Cystic Fibrosis 8. For treatment of cancers 9. For treating cancer For increasing milk yield.

Switch Flag Bookmark. It is the process in which multiple copies of the gene or segment of DNA of interest are synthesised in vitro using primers and DNA polymerase.

It involves three basic steps; denaturation, annealing and extension polymerisation. From what you have learnt, can you tell whether enzymes are bigger or DNA is bigger in molecular size. How did you know? DNA molecules are bigger in size as compared to enzymes. Enzymes are proteins which are synthesized from a small portion of DNA called genes therefore they are smaller than DNA molecules.

Describe briefly the following : a Origin of replication b Bioreactor c Downstream processing. It is a specific sequence of DNA bases, which initiates replication. This sequence controls the copy number of linked DNA. Media, Mass Communication and Journalism Change.

Quick Links B. Com M. Go To Your Study Dashboard. Post Answer. S Sonika. Some of the proteins produced through RDT and are being used for therapeutic uses are as follows: S. No Name of the recombinant protein Therapeutic use of the recombinant protein 1. DNAase I To treat cystic fibrosis 2.

Antithrombin III To prevent the formation of the blood clot 3. Insulin To treat type I diabetes mellitus 4. Interferon Used for chronic hepatitis C 5. Interferon AZA Used for herpes and virus enteritis 6. Coagulation factor IX To treat haemophilia B 8. Interferon B To treat multiple sclerosis 9. National Center for Biotechnology Information , U. Journal List Int Arch Med v. Int Arch Med. Published online Apr Antonio Liras 1.

Author information Article notes Copyright and License information Disclaimer. Corresponding author. Antonio Liras: moc. Received Jan 23; Accepted Apr This article has been cited by other articles in PMC. Abstract One of the most spectacular advances in the history of scientific knowledge was the discovery of deoxyribonucleic acid DNA by Watson and Crick in Open in a separate window.

Figure 1. Significant events related to therapeutic recombinant proteins. Table 1 Some recombinant proteins used in clinical treatment. Protein Clinical utility Coagulant factors Haemophilia A and B DNase I Cystic fibrosis Erythropoietin Anaemia in chronic renal disease Glucocerebrosidase Gaucher disease Growth hormone Nanism hypophyseal Insulin Diabetes Alpha interferon Some leukaemias, Kaposi's sarcoma, hepatitis B and C Gamma-1b interferon Chronic granulomatous disease Interleukin-2, -3 and -4 Immunotherapy of cancer Tissue-type plasminogen activator Acute myocardial infarction, massive pulmonary embolism Antibodies for cellular immunotherapy Neoplasic processes Vaccines Influenza, hepatitis A and B Monoclonal antibodies anti-antibodies Lupus, rheumatoid arthritis.

A structure for deoxyribose nucleic acid. Safety of growth hormone replacement therapy in adults. Expert Opin Drug Saf. Phase I comparability of recombinant human albumin and human serum albumin. J Clin Pharmacol. The promise of third-generation recombinant therapy and gene therapy. Semin Hematol. Treating haemophilia A with recombinant blood factors: A comparison. Expert Opin Pharmacother. Neuropathology and molecular biology of variant Creutzfeldt-Jakob disease. Curr Top Microbiol Immunol.

Managing the risk of transmission of variant Creutzfeldt Jakob disease by blood products.